The research themes in my lab aim to decipher the stem cell biology, tissue engineering and biomaterial development important for biomedicine application. We have combined the bionanotechnology approaches to address the relevant novel surface modification techniques in vascular tissue engineering application.

Immunomodulation (Dendritic cell and Adipose-derived stem cells)
Alternative splicing regulation (glioblastoma and Parkinson’s disease)
Neurodegenerative diseases (stroke, Parkinson’s disease and ALS); C. elegans model

Dr. Ming-You Shie’s research encompasses biomedical engineering, regenerative medicine, and translational medicine. In recent years, he has focused on integrating biomaterials, biofabrication, and engineered biological nanocarriers to develop therapeutic platforms with strong clinical potential for tissue repair, cancer, chronic diseases, and neurodegenerative disorders. Over the past five years, his achievements have included multiple patents and technology translation projects. He has also received several prestigious honors, including recognition among the World’s Top 2% Scientists, The National Innovation Award, and The Future Tech Award several times.

Biomaterials、clinical trial、Cell Biology、Medical Regulations、Animal Study

Mitochondria & Extracellular vesicle modification Biomedical Engineering Tissue Regeneration Molecular Cancer Medicine 3D printing

Dr. Yen-Hong Lin has an interdisciplinary background in computer science and biomedical engineering. His research focuses on 3D-printed biomedical materials, tissue engineering, regenerative medicine, and engineered extracellular vesicles. In recent years, he has developed strategies to enhance extracellular vesicle production and biological functions and explored their applications in bone regeneration, chronic wound healing, nerve repair, and the treatment of neurodegenerative diseases.

Research Assistant Min-Hua Yu is deeply engaged in the fields of translational and regenerative medicine, characterized by an approachable demeanor and a rigorous, responsible work ethic. Her experimental expertise is extensive; she is highly proficient in molecular biology techniques such as CRISPR and flow cytometry, and possesses rich experience in exosome production and drug loading. Furthermore, she is well-versed in various in vivo animal studies and xenotransplantation, capable of expertly executing complex procedures including the establishment of orthotopic cancer models, biodistribution assays, and porcine nuclear transfer. With her steady execution and solid practical experience, she effectively drives experimental progress, making her a highly reliable partner in advancing new drug development projects and maintaining daily laboratory operations.